Familial aggregation of early‐onset cancers
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چکیده
منابع مشابه
Familial Aggregation of Stroke
Stroke is the second leading cause of death worldwide, and the leading cause of acquired disability in adults in most regions. Fifteen million people worldwide suffer a stroke each year with devastating effects; one third of these individuals die and another one third remains permanently disabled. However, there is a considerable additional unreported asymptomatic cerebrovascular disease. Accor...
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PURPOSE Most colorectal cancers that have high levels of microsatellite instability (MSI-H) show loss of immunohistochemical expression of proteins that participate in the DNA mismatch repair process, most often involving MLH1 and MSH2. Less commonly, a third DNA mismatch repair protein, MSH6, may also be lost as the primary event. Rarely, tumors with MSI-H show normal expression of these three...
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Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems play a role in the e...
متن کاملTesting familial aggregation.
Likelihood calculation for pedigrees is complicated and often time-consuming. Testing correlation structures due to familial aggregation is therefore a preliminary procedure. A score statistic is given to check correlations between relatives of randomly chosen pedigrees. This statistic can be used for quantitative and dichotomous data. For both data types, the distribution of the statistic unde...
متن کاملFamilial aggregation of absolute pitch.
Absolute pitch (AP) is a behavioral trait that is defined as the ability to identify the pitch of tones in the absence of a reference pitch. AP is an ideal phenotype for investigation of gene and environment interactions in the development of complex human behaviors. Individuals who score exceptionally well on formalized auditory tests of pitch perception are designated as "AP-1." As described ...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2019
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.32512